Research Interests
Mapping and shaping causal dynamics in human brain networks:My main interest is to study the causal dynamic interactions between brain regions in the human brain. I explore how these interactions support human brain function with a focus on motor control and decision-making. I combine advanced functional brain mapping techniques with interventions such as non-invasive transcranial brain stimulation (NTBS), training, or pharmacological manipulations. This “causal” research strategy allows me to identify and shape the network dynamics that determine human brain function in health and disease.Pathogenesis and pathophysiology of brain disorders:I use multimodal brain imaging to cast new light on the pathogenesis and pathophysiology of major brain disorders such as Parkinson ́s disease, multiple sclerosis, dystonia, Tourette syndrome, affective disorders, and schizophrenia. Adopting a pharmaco-fMRI approach, I identified an acute motor network response to levo-dopa therapy that predicted the emergence of medication-induced dyskinesia in patients with Parkinson´s disease.Determinants of brain function and brain plasticity across the lifespan:Another line of research is designed to identify structural or functional correlates in the brain that underlie behavioral traits and individual preferences. My neuroimaging research on handedness yielded important insights into how nature and nurture shape brain function and structure in the motor system.
